Dcc^tm1.1Mehl
Targeted Allele Detail

Summary

• Symbol: Dcc^tm1.1Mehl
• Name: DCC netrin 1 receptor; targeted mutation 1.1, Patrick Mehlen
• MGI ID: MGI:5312257
• Synonyms: DCC^mut
• Gene: Dcc Location: Chr18:71386705-72484140 bp, - strand Genetic Position: Chr18, 45.24 cM
• Alliance: Dcc^tm1.1Mehl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181517
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A G to A nucleotide substitution in exon 26 resulted in an aspartic acid to asparagine substitution at codon 1290 (D1290N). In addition a floxed neo cassette was inserted in an adjacent intron. The selection cassette was subsequently removed by cre recombinase. (J:181517)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dcc Mutation: 76 strains or lines available

References

• Original: J:181517 Castets M, et al., DCC constrains tumour progression via its dependence receptor activity. Nature. 2012 Feb 23;482(7386):534-7
• All: 2 reference(s)