Mss51^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Mss51^{tm1(KOMP)Vlcg}
• Name: MSS51 mitochondrial translational activator; targeted mutation 1, Velocigene
• MGI ID: MGI:5312367
• Synonyms: Zmynd17^LacZ
• Gene: Mss51 Location: Chr14:20532935-20546969 bp, - strand Genetic Position: Chr14, 11.53 cM, cytoband B
• Alliance: Mss51^{tm1(KOMP)Vlcg} page
• IMPC: Mss51 gene page

Mutation origin

• Mutant Cell Lines: 14311E-C1, 14311E-G5, 14311E-G12
• Germline Transmission: Earliest citation of germline transmission: J:280597
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 4599bp between positions 20533128-20537726 of Chromosome 14 (Build GRCm39). (J:136110)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Mss51^tm1(KOMP)Vlcg/Mss51^tm1(KOMP)Vlcg	involves: C57BL/6NTac	14311E-G5

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
adipose tissue	√
decreased inguinal fat pad weight	√
behavior/neurological	√
decreased aerobic running capacity	√
cellular	√
abnormal mitochondrial morphology	√
increased mitochondrial DNA content	√
abnormal mitochondrial crista morphology	√
abnormal mitochondrial shape	√
abnormal mitochondrial physiology	√
growth/size/body	√
increased liver weight	√
homeostasis/metabolism	√
decreased aerobic running capacity	√
increased fasting circulating glucose level	√
increased circulating insulin level	√
impaired glucose tolerance	√
increased skeletal muscle glycogen level	√
insulin resistance	√
liver/biliary system	√
increased liver weight	√
hepatic steatosis	√
muscle	√
abnormal muscle morphology	√
increased skeletal muscle glycogen level	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Mss51 Mutation: 19 strains or lines available

Notes

Mutant cell line 14311E-G5 was used to create mutant mice which demonstrated germline transmission. J:280597.

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 3 reference(s)