Vldlr^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Vldlr^tm1Lex
• Name: very low density lipoprotein receptor; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5312686
• Gene: Vldlr Location: Chr19:27193884-27231631 bp, + strand Genetic Position: Chr19, 21.77 cM
• Alliance: Vldlr^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181399
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Exons 4 and 5 were replaced with a beta-geo/Puro cassette. (J:181399)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vldlr Mutation: 69 strains or lines available

References

• Original: J:181399 Paes KT, et al., Frizzled 4 is required for retinal angiogenesis and maintenance of the blood-retina barrier. Invest Ophthalmol Vis Sci. 2011 Aug;52(9):6452-61
• All: 1 reference(s)