Dpysl2^tm1.1Gosh
Targeted Allele Detail

Summary

• Symbol: Dpysl2^tm1.1Gosh
• Name: dihydropyrimidinase-like 2; targeted mutation 1.1, Yoshio Goshima
• MGI ID: MGI:5312892
• Synonyms: crmp2^ki
• Gene: Dpysl2 Location: Chr14:67040313-67106137 bp, - strand Genetic Position: Chr14, 34.6 cM
• Alliance: Dpysl2^tm1.1Gosh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180581
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A floxed neo cassette was inserted upstream of exon 13 and a T to G mutation was introduced in exon 13 resulting in a Ser to Ala substitution at position 522 (S522A). Cre mediated recombination removed the neo cassette. In brain lysates from homozygous mice phosphorylation of Ser522 and Thr509 is completely suppressed. (J:180581)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpysl2 Mutation: 34 strains or lines available

References

• Original: J:180581 Yamashita N, et al., Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization. J Neurosci. 2012 Jan 25;32(4):1360-1365
• All: 7 reference(s)