Mirc33^tm1Bdes
Targeted Allele Detail

Summary

• Symbol: Mirc33^tm1Bdes
• Name: microRNA cluster 33, including Mir29a through Mir29b-1; targeted mutation 1, Bart de Stropper
• MGI ID: MGI:5312902
• Synonyms: Mir29a/Mir29b-1^tm1Alis, Mir29-aMir29b-1^tm1Bds
• Gene: Mirc33 Location: Chr6:31039595-31040028 bp Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A 1.7 kb region including the full coding sequence for both miroRNAs (Mir29a and Mir29b-1) was replaced with a hygromycin cassette via homologous recombination. In situ hybridization confirmed the absence of mir29a expression in the thymus of homozygous mice. (J:180783)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc33 Mutation: 0 strains or lines available

References

• Original: J:180783 Papadopoulou AS, et al., The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-alpha receptor. Nat Immunol. 2012 Feb;13(2):181-7
• All: 10 reference(s)