Tg(Hnf1a-RB1*)XMiu
Transgene Detail
|
|
| Symbol: |
Tg(Hnf1a-RB1*)XMiu |
| Name: |
transgene insertion X, Naoyuki Miura |
| MGI ID: |
MGI:5312916 |
| Synonyms: |
mt-Rb, TGX |
| Transgene: |
Tg(Hnf1a-RB1*)XMiu Location: unknown
|
| Alliance: |
Tg(Hnf1a-RB1*)XMiu page
|
|
| Strain of Origin: |
Not Specified
|
|
| Transgene Type: |
|
Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
|
Insertion
|
| |
|
Mutation details: The rat Hnf1a enhancer/promoter drives expression of a phosphorylation-resistant mutant human RB1 cDNA. Phosphorylation resistance was created by mutating 12 of 16 consensus phosphorylation sites (8 serines and 4 threonines) to alanines. High levels of transgene expression are detected in the livers of mice in this line.
(J:180294)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:180294 Wang B, et al., Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an upregulation of c-Myc target genes. Biochem Biophys Res Commun. 2012 Jan 6;417(1):601-6 |
| All: |
1 reference(s) |
|
Analysis Tools
