Fbn1^tm3.1Lysa
Targeted Allele Detail

Summary

• Symbol: Fbn1^tm3.1Lysa
• Name: fibrillin 1; targeted mutation 3.1, Lynn Y Sakai
• MGI ID: MGI:5313326
• Synonyms: Fbn1^{floxed WMdelta}
• Gene: Fbn1 Location: Chr2:125142514-125348417 bp, - strand Genetic Position: Chr2, 61.38 cM, cytoband F
• Alliance: Fbn1^tm3.1Lysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181493
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 10. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 10. An additional loxP site was inserted downstream of exon 12. Flp-mediated recombination removed the neo cassette leaving exons 10 and 11 floxed. (J:181493)

Generation of the Fbn1^tm3.1Lysa and Fbn1^tm3.2Lysa alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbn1 Mutation: 173 strains or lines available

References

• Original: J:181493 Sengle G, et al., Microenvironmental regulation by fibrillin-1. PLoS Genet. 2012 Jan;8(1):e1002425
• All: 1 reference(s)