Rr17^tm1.1Cdon
Targeted Allele Detail

Summary

• Symbol: Rr17^tm1.1Cdon
• Name: regulatory region 17; targeted mutation 1.1, Chen Dong
• MGI ID: MGI:5313386
• Synonyms: CNS2^-
• Gene: Rr17 Location: unknown Genetic Position: Chr1, Syntenic
• Alliance: Rr17^tm1.1Cdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181186
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced the conserved noncoding sequence 2 (CNS2), located 2 kb upstream of Il17a and 56.5 kb away from Il17f. Cre-mediated recombination removed the neo cassette. ELISA confirmed the reduction in protein expression of Il17a and Il17f in T cells under Th17 conditions. (J:181186)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr17 Mutation: 0 strains or lines available

References

• Original: J:181186 Wang X, et al., Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity. 2012 Jan 27;36(1):23-31
• All: 1 reference(s)