Bcl2^tm1.1Sjk
Targeted Allele Detail

Summary

• Symbol: Bcl2^tm1.1Sjk
• Name: B cell leukemia/lymphoma 2; targeted mutation 1.1, Stanley Korsmeyer
• MGI ID: MGI:5313428
• Synonyms: Bcl2^AAA, Bcl2^tm1.1Blev
• Gene: Bcl2 Location: Chr1:106465908-106642004 bp, - strand Genetic Position: Chr1, 49.76 cM
• Alliance: Bcl2^tm1.1Sjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181308
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions in exon 2 were used to replace the threonine at 69 and serines at positions 70 and 84 with alanines (T69A, S70A and S84A). Flp-mediated recombination removes the puro cassette inserted downstream of the modified exon 2. (J:181308)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl2 Mutation: 41 strains or lines available

References

• Original: J:181308 He C, et al., Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 2012 Jan 26;481(7382):511-5
• All: 8 reference(s)