Tg(CRYBB1-CRYGC*)#Jfhe
Transgene Detail

Summary

• Symbol: Tg(CRYBB1-CRYGC*)#Jfhe
• Name: transgene insertion, J Fielding Hejtmancik
• MGI ID: MGI:5313507
• Synonyms: CRYGC5bpd, OGO2
• Transgene: Tg(CRYBB1-CRYGC*)#Jfhe Location: unknown
• Alliance: Tg(CRYBB1-CRYGC*)#Jfhe page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CRYBB1-CRYGC*)#Jfhe expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CRYGC (1420)

  Crygc

  (MGI:88523)

• Tg(CRYBB1-CRYGC*)#Jfhe expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CRYBB1 (374000)

• Mutation details: This transgene consists of the chicken betaB1-crystallin promoter followed by the human gammaC-crystallin cDNA with a 5 bp duplication in exon 2 (c.119_123dup), the mouse betaA3/A1-crystallin gene splice site including the last 1055 bp of exon 5, intron 5, and exon 6 and the polyadenylation signal. The 5 bp insertion is predicted to result in an amino acid sequence frameshift that produces a new protein comprised of the first 41 amino acids of CRYGC followed by 62 novel amino acids and a new stop codon. (J:181433)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:181433 Ma Z, et al., Overexpression of human gammaC-crystallin 5 bp duplication disrupts lens morphology in transgenic mice. Invest Ophthalmol Vis Sci. 2011 Jul;52(8):5369-75
• All: 1 reference(s)