Mavs^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Mavs^tm1Itl
• Name: mitochondrial antiviral signaling protein; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:5313532
• Gene: Mavs Location: Chr2:131075983-131089945 bp, + strand Genetic Position: Chr2, 63.3 cM
• Alliance: Mavs^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181257
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 2 and 3. Northern blot and qPCR analyses confirm the absence of transcript expression. (J:181257, J:187927)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mavs Mutation: 36 strains or lines available

References

• Original: J:181257 Gall A, et al., Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity. 2012 Jan 27;36(1):120-31
• All: 12 reference(s)