b2b508.2Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b508.2Clo
• Name: Mutant line 508, subline 2; Bench to Bassinet Program (B2B/CVDC), mutation 508, subline 2 Cecilia Lo
• MGI ID: MGI:5313992
• Gene: b2b508.2Clo Location: unknown
• Alliance: b2b508.2Clo page

Mutant 508-005-NA shows craniofacial defect with anencephaly.

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. It is a subline of b2b508Clo. Additional incidental mutations were detected in sequencing for the causative mutation, b2b508.2Clo, and may be present in stocks carrying this mutation.

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b508.2Clo Mutation: 1 strain or line available

Notes

This mutation was derived from the parent line b2b508Clo.

Summative Diagnosis:
Mutant Phenotype II: Cardiac defects: VSD Noncardiac defects: Anencephaly, anopthalmia, hypoplasia of the oral cavity, micrognathia, holosprosencephaly

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
1300	Ventricular septal defect
4163	Micrognathia
4864	Anophthalmia
4332	Anencephaly
4338	Holoprosencephaly

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)