Clec1b^tm1.2Arte
Targeted Allele Detail

Summary

• Symbol: Clec1b^tm1.2Arte
• Name: C-type lectin domain family 1, member b; targeted mutation 1.2, TaconicArtemis
• MGI ID: MGI:5314118
• Gene: Clec1b Location: Chr6:129374260-129382376 bp, + strand Genetic Position: Chr6, 63.3 cM, cytoband F3
• Alliance: Clec1b^tm1.2Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181754
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Clec1b^tm1.1Arte removed exons 3 and 4. Western blot analysis confirmed the absence of protein expression in platelets from irradiated mice reconstituted with knock-out fetal livers. (J:181754)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec1b Mutation: 17 strains or lines available

References

• Original: J:181754 Hughes CE, et al., CLEC-2 is not required for platelet aggregation at arteriolar shear. J Thromb Haemost. 2010 Oct;8(10):2328-32
• All: 5 reference(s)