Syk^tm1.1Nns
Targeted Allele Detail

Summary

• Symbol: Syk^tm1.1Nns
• Name: spleen tyrosine kinase; targeted mutation 1, Nicholas N Smithers
• MGI ID: MGI:5314125
• Synonyms: Syk^fl
• Gene: Syk Location: Chr13:52737209-52802828 bp, + strand Genetic Position: Chr13, 27.41 cM, cytoband B-C2
• Alliance: Syk^tm1.1Nns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181715
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 11 was floxed. Cre-mediated recombination removes the floxed neo cassette. (J:181715)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syk Mutation: 42 strains or lines available

References

• Original: J:181715 Finney BA, et al., CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood. 2012 Feb 16;119(7):1747-56
• All: 5 reference(s)