Hesx1^tm4.1Jpmb
Targeted Allele Detail

Summary

• Symbol: Hesx1^tm4.1Jpmb
• Name: homeobox gene expressed in ES cells; targeted mutation 4.1, Juan Pedro Martinez Barbera
• MGI ID: MGI:5314527
• Synonyms: Hesx1^eGFP
• Gene: Hesx1 Location: Chr14:26716373-26724286 bp, + strand Genetic Position: Chr14, 16.09 cM, cytoband A3-B
• Alliance: Hesx1^tm4.1Jpmb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181005
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced with a reporter cassette that contained a floxed EGFP and 5x polyadenylation sites, DTA and FRT-flanked neo cassette. Flp-mediated recombination removed the neo cassette. (J:181005)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hesx1 Mutation: 14 strains or lines available

References

• Original: J:181005 Andoniadou CL, et al., HESX1- and TCF3-mediated repression of Wnt/beta-catenin targets is required for normal development of the anterior forebrain. Development. 2011 Nov;138(22):4931-42
• All: 1 reference(s)