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Hprt1tm2(CAG-TBX2,-EGFP)Akis
Targeted Allele Detail
Summary
Symbol: Hprt1tm2(CAG-TBX2,-EGFP)Akis
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Andreas Kispert
MGI ID: MGI:5314539
Synonyms: HpCT2
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm2(CAG-TBX2,-EGFP)Akis page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:181526
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Hprt1tm2(CAG-TBX2,-EGFP)Akis expresses 1 gene
 
Mutation detailsExon 1 was replaced with a CAG promoter, loxP site, neo/stop cassette, loxP2272 site, inverted human TBX2 cDNA, IRES and EGFP cassette, loxP site, and loxP2272 site. Cre-mediated recombination is required to achieve expression of TBX2 and EGFP. (J:181526)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1279 strains or lines available
References
Original:  J:181526 Singh R, et al., Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation. Cell Mol Life Sci. 2012 Apr;69(8):1377-89
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory