Tg(GAL4-PABPN1*A16)#Cath
Transgene Detail

Summary

• Symbol: Tg(GAL4-PABPN1*A16)#Cath
• Name: transgene insertion, Charles A Thornton
• MGI ID: MGI:5314745
• Synonyms: GAL4-tk-PABmut
• Transgene: Tg(GAL4-PABPN1*A16)#Cath Location: unknown
• Alliance: Tg(GAL4-PABPN1*A16)#Cath page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(GAL4-PABPN1*A16)#Cath expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PABPN1 (8106)

  Pabpn1

  (MGI:1859158)

• Mutation details: This transgene consists of a human PABPN1 minigene with an insertion of an additional six alanine codons to the polyalanine tract (for a total of 16 alanines) under the control of four GAL4 response elements linked to the minimal thymidine kinase promoter. Four lines were made, however the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:178541)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:178541 Mankodi A, et al., Progressive myopathy in an inducible mouse model of oculopharyngeal muscular dystrophy. Neurobiol Dis. 2012 Jan;45(1):539-46
• All: 1 reference(s)