Src^tm1Mul
Targeted Allele Detail

Summary

• Symbol: Src^tm1Mul
• Name: Rous sarcoma oncogene; targeted mutation 1, William J Muller
• MGI ID: MGI:5314758
• Synonyms: c-Src^L
• Gene: Src Location: Chr2:157265828-157313758 bp, + strand Genetic Position: Chr2, 78.35 cM
• Alliance: Src^tm1Mul page

Analysis of tumorigenesis

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181822
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo, IRES, and GFP cassette with a 3' loxP site downstream of exon 6. Flp-mediated recombination removed the neo, IRES and GFP cassette. (J:181822)

(A) Generation of the conditional Src^tm1Mul allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Src Mutation: 146 strains or lines available

References

• Original: J:181822 Marcotte R, et al., Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2808-13
• All: 6 reference(s)