Lhx8^tm2.1Vpa
Targeted Allele Detail

Summary

• Symbol: Lhx8^tm2.1Vpa
• Name: LIM homeobox protein 8; targeted mutation 2.1, Vassilis Pachnis
• MGI ID: MGI:5314801
• Synonyms: Lhx7^fl
• Gene: Lhx8 Location: Chr3:154011925-154036190 bp, - strand Genetic Position: Chr3, 79.12 cM, cytoband H3-H4
• Alliance: Lhx8^tm2.1Vpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182013
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 4 and a loxP site was inserted downstream of exon 4 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 4 floxed. (J:182013)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx8 Mutation: 25 strains or lines available

References

• Original: J:182013 Lopes R, et al., Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3119-24
• All: 2 reference(s)