Huwe1^tm1.1Mak
Targeted Allele Detail

Summary

• Symbol: Huwe1^tm1.1Mak
• Name: HECT, UBA and WWE domain containing 1; targeted mutation 1.1, Tak Mak
• MGI ID: MGI:5314816
• Synonyms: Mule^fl
• Gene: Huwe1 Location: ChrX:150583803-150718413 bp, + strand Genetic Position: ChrX, 68.46 cM
• Alliance: Huwe1^tm1.1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181705
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 76. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 77. Flp-mediated recombination removed the neo cassette and left exons 76 and 77 floxed. (J:181705)

Generation of the Huwe1^tm1.1Mak and Huwe1^tm1.2Mak alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Huwe1 Mutation: 63 strains or lines available

References

• Original: J:181705 Hao Z, et al., The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis. J Exp Med. 2012 Jan 16;209(1):173-86
• All: 7 reference(s)