Lrp2^{tm2(EGFP/cre)Tew}
Targeted Allele Detail

Summary

• Symbol: Lrp2^{tm2(EGFP/cre)Tew}
• Name: low density lipoprotein receptor-related protein 2; targeted mutation 2, Thomas E Willnow
• MGI ID: MGI:5314898
• Synonyms: Lrp2^tmEGFP
• Gene: Lrp2 Location: Chr2:69254679-69416373 bp, - strand Genetic Position: Chr2, 40.74 cM
• Alliance: Lrp2^{tm2(EGFP/cre)Tew} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181474
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Lrp2^{tm2(EGFP/cre)Tew} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lrp2 (MGI:95794)

• Mutation details: A minigene construct contained intron 1 of the rabbit beta-globin sequence followed by an EGFP/cre fusion gene with a nuclear localization signal and a translational stop codon. Homologous recombination in ES cells replaced exon 1 and 3.6 kb of intron 1 of the Lrp2 locus with the EGFP/cre minigene. (J:181474)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lrp2 (mouse) Summary of all recombinase alleles driven by Lrp2. Alliance mouse Lrp2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp2 Mutation: 261 strains or lines available

References

• Original: J:181474 Christ A, et al., LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals. Dev Cell. 2012 Feb 14;22(2):268-78
• All: 1 reference(s)