Ror1^tm1.1Meg
Targeted Allele Detail

Summary

• Symbol: Ror1^tm1.1Meg
• Name: receptor tyrosine kinase-like orphan receptor 1; targeted mutation 1.1, Michael E Greenberg
• MGI ID: MGI:5315483
• Synonyms: Ror1^f
• Gene: Ror1 Location: Chr4:99952988-100301962 bp, + strand Genetic Position: Chr4, 45.71 cM, cytoband C6
• Alliance: Ror1^tm1.1Meg page

Ror1^tm1.1Meg/Ror1^tm1.1Meg Ror2^tm1.1Meg/Ror2^tm1.1Meg H2az2^{Tg(Wnt1-cre)11Rth}/0 embryos exhibit sympathetic axon branching defects

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182150
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. Western blot analysis confirms protein expression in homozygous mice is similar to wild-type levels. (J:182150)

Generation of the Ror1^tm1.1Meg and Ror1^tm1.2Meg alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ror1 Mutation: 58 strains or lines available

References

• Original: J:182150 Ho HY, et al., Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51
• All: 8 reference(s)