Ror1^tm1.2Meg
Targeted Allele Detail

Summary

• Symbol: Ror1^tm1.2Meg
• Name: receptor tyrosine kinase-like orphan receptor 1; targeted mutation 1.2, Michael E Greenberg
• MGI ID: MGI:5315484
• Synonyms: Ror1^-, Ror1^d
• Gene: Ror1 Location: Chr4:99952988-100301962 bp, + strand Genetic Position: Chr4, 45.71 cM, cytoband C6
• Alliance: Ror1^tm1.2Meg page

Rare exencephaly in Ror1^tm1.2Meg/Ror1^tm1.2Meg mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182150
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Flp-mediated recombination removed the neo cassette. Exons 3 and 4 were deleted through cre-mediated recombination. Western blot analysis confirms absence of protein expression in homozygous mice. (J:182150)

Generation of the Ror1^tm1.1Meg and Ror1^tm1.2Meg alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ror1 Mutation: 58 strains or lines available

References

• Original: J:182150 Ho HY, et al., Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51
• All: 1 reference(s)