Ror2^tm1.1Meg
Targeted Allele Detail

Summary

• Symbol: Ror2^tm1.1Meg
• Name: receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1.1, Michael E Greenberg
• MGI ID: MGI:5315485
• Synonyms: Ror2^f
• Gene: Ror2 Location: Chr13:53263353-53440160 bp, - strand Genetic Position: Chr13, 27.68 cM, cytoband B3
• Alliance: Ror2^tm1.1Meg page

Ror1^tm1.1Meg/Ror1^tm1.1Meg Ror2^tm1.1Meg/Ror2^tm1.1Meg H2az2^{Tg(Wnt1-cre)11Rth}/0 embryos exhibit sympathetic axon branching defects

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182150
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A lox2272 site was inserted upstream of exon 3 and an FRT flanked neo cassette and lox2272 site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. Western blot analysis confirms protein expression in homozygous mice is similar to wild-type levels. (J:182150)

Generation of Ror2^tm1.1Meg and Ror2^tm1.2Meg alleles

Expression

In Mice Carrying this Mutation:

22 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ror2 Mutation: 125 strains or lines available

References

• Original: J:182150 Ho HY, et al., Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51
• All: 18 reference(s)