Ror2^tm1.2Meg
Targeted Allele Detail

Summary

• Symbol: Ror2^tm1.2Meg
• Name: receptor tyrosine kinase-like orphan receptor 2; targeted mutation 1.2, Michael E Greenberg
• MGI ID: MGI:5315486
• Synonyms: Ror2^-, Ror2^d
• Gene: Ror2 Location: Chr13:53263353-53440160 bp, - strand Genetic Position: Chr13, 27.68 cM, cytoband B3
• Alliance: Ror2^tm1.2Meg page

Morphogenesis defects in Ror2^tm1.2Meg/Ror2^tm1.2Meg mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182150
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 4 via homologous recombination. Recombinase-mediated recombination removed the neo cassette and exons 3 and 4. Western blot analysis confirms the absence of protein expression in homozygous embryos. (J:182150)

Generation of Ror2^tm1.1Meg and Ror2^tm1.2Meg alleles

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ror2 Mutation: 125 strains or lines available

References

• Original: J:182150 Ho HY, et al., Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51
• All: 1 reference(s)