Col27a1^tm1.1Rpbh
Targeted Allele Detail

Summary

• Symbol: Col27a1^tm1.1Rpbh
• Name: collagen, type XXVII, alpha 1; targeted mutation 1.1, Raymond P Boot-Handford
• MGI ID: MGI:5315592
• Synonyms: Col27G1516C, M^G/C
• Gene: Col27a1 Location: Chr4:63132246-63253228 bp, + strand Genetic Position: Chr4, 33.96 cM, cytoband C1
• Alliance: Col27a1^tm1.1Rpbh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182341
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Single point mutation
• Mutation details: A loxP site was inserted upstream of exon 50, a G to C mutation was introduced at position 1516 in exon 50, and a floxed neo cassette was inserted downstream of exon 55 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:182341)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col27a1 Mutation: 79 strains or lines available

References

• Original: J:182341 Plumb DA, et al., Collagen XXVII organises the pericellular matrix in the growth plate. PLoS One. 2011;6(12):e29422
• All: 1 reference(s)