Cdo1^tm1.1Mhst
Targeted Allele Detail

Summary

• Symbol: Cdo1^tm1.1Mhst
• Name: cysteine dioxygenase 1, cytosolic; targeted mutation 1.1, Martha H Stipanuk
• MGI ID: MGI:5315594
• Gene: Cdo1 Location: Chr18:46846260-46861462 bp, - strand Genetic Position: Chr18, 24.75 cM
• Alliance: Cdo1^tm1.1Mhst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182195
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: One loxP site was inserted upstream of exon 3 while an FRT flanked neo cassette followed by a second loxP site was inserted downstream. Properly targeted homozygous mice were bred to cre-deleter mice to excise exon 3 and the neo selection cassette. (J:182195)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdo1 Mutation: 19 strains or lines available

References

• Original: J:182195 Ueki I, et al., Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide. Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E668-84
• All: 3 reference(s)