Mirc6^tm1.1Mtm
Targeted Allele Detail

Summary

• Symbol: Mirc6^tm1.1Mtm
• Name: microRNA cluster 6, including Mir379 through Mir544; targeted mutation 1.1, Michael McManus
• MGI ID: MGI:5315602
• Synonyms: miR-654/376b
• Gene: Mirc6 Location: Chr12:109675494-109695836 bp Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181752
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intergenic deletion
• Mirc6^tm1.1Mtm involves 2 genes/genome features (Mir654, Mir376b) View all
• Mutation details: Cre-mediated recombination removed the neo cassette and the microRNA cluster stem loop from Mirc6^tm1Mtm. qRT-PCR analysis confirmed the loss of the microRNA. Beta-galactosidase expression is observed in frontal portion of rib cage in E18.5 and adult. (J:181752)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc6 Mutation: 3 strains or lines available

References

• Original: J:181752 Park CY, et al., A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012;1(4):385-91
• All: 2 reference(s)