Mirc31^tm1.1Mtm
Targeted Allele Detail

Summary

• Symbol: Mirc31^tm1.1Mtm
• Name: microRNA cluster 31, including Mirlet7c-2 through Mirlet7b; targeted mutation 1.1, Michael McManus
• MGI ID: MGI:5315606
• Synonyms: let-7c-2/let-7b
• Gene: Mirc31 Location: Chr15:85590804-85591604 bp Genetic Position: Chr15, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181831
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Cre-mediated recombination removed the neo cassette and the microRNA cluster stem loop from Mirc31^tm1Mtm. qRT-PCR analysis confirmed the loss of the microRNA. Beta-galactosidase expression is observed in embryonic brainand spinal cord. (J:181831)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc31 Mutation: 2 strains or lines available

References

• Original: J:181831 W.M. Keck Center for Noncoding RNAs, Information obtained from the W.M. Keck Center for Noncoding RNAs. Unpublished. 2012
• All: 2 reference(s)