Slc12a5^tm2.1Tjj
Targeted Allele Detail

Summary

• Symbol: Slc12a5^tm2.1Tjj
• Name: solute carrier family 12, member 5; targeted mutation 2.1, Thomas J Jentsch
• MGI ID: MGI:5315721
• Synonyms: Kcc2^loxP
• Gene: Slc12a5 Location: Chr2:164802766-164841651 bp, + strand Genetic Position: Chr2, 85.28 cM, cytoband G2-G3
• Alliance: Slc12a5^tm2.1Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181930
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 1. An additional loxP site was inserted into intron 5. Cre-mediated recombination removed the neo cassette and left exons 2 through 5 floxed. (J:181930)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a5 Mutation: 45 strains or lines available

References

• Original: J:181930 Seja P, et al., Raising cytosolic Cl(-) in cerebellar granule cells affects their excitability and vestibulo-ocular learning. EMBO J. 2012 Mar 7;31(5):1217-30
• All: 7 reference(s)