Slc12a6^tm1.1Tjj
Targeted Allele Detail

Summary

• Symbol: Slc12a6^tm1.1Tjj
• Name: solute carrier family 12, member 6; targeted mutation 1.1, Thomas J Jentsch
• MGI ID: MGI:5315722
• Synonyms: Kcc3^loxP
• Gene: Slc12a6 Location: Chr2:112096659-112193508 bp, + strand Genetic Position: Chr2, 56.99 cM
• Alliance: Slc12a6^tm1.1Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181930
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted into intron 4. An additional loxP site was inserted into intron 6. Cre-mediated recombination removed the neo cassette and left exons 5 and 6 floxed. (J:181930)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a6 Mutation: 120 strains or lines available

References

• Original: J:181930 Seja P, et al., Raising cytosolic Cl(-) in cerebellar granule cells affects their excitability and vestibulo-ocular learning. EMBO J. 2012 Mar 7;31(5):1217-30
• All: 2 reference(s)