Prdm8^tm1Mci
Targeted Allele Detail

Summary

• Symbol: Prdm8^tm1Mci
• Name: PR domain containing 8; targeted mutation 1, Roderick R McInnes
• MGI ID: MGI:5315763
• Synonyms: Prdm8^EGFP
• Gene: Prdm8 Location: Chr5:98315241-98335313 bp, + strand Genetic Position: Chr5, 47.77 cM, cytoband E3
• Alliance: Prdm8^tm1Mci page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182304
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The second and third exon was replaced with an IRES-EGFP. Western blot analysis confirmed the absence of protein expression in the cortex. (J:182304)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Prdm8 Mutation: 21 strains or lines available

References

• Original: J:182304 Ross SE, et al., Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Neuron. 2012 Jan 26;73(2):292-303
• All: 2 reference(s)