Huwe1^tm1Wgu
Targeted Allele Detail

Summary

• Symbol: Huwe1^tm1Wgu
• Name: HECT, UBA and WWE domain containing 1; targeted mutation 1, Wei Gu
• MGI ID: MGI:5315772
• Synonyms: arf-bp1^FL
• Gene: Huwe1 Location: ChrX:150583803-150718413 bp, + strand Genetic Position: ChrX, 68.46 cM
• Alliance: Huwe1^tm1Wgu page

Loss of pancreatic beta-cells in aged Huwe1^tm1Wgu/Y Tg(Ins2-cre)23Herr/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182446
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 11. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 11. (J:182446)

Generation of the floxed Huwe1^tm1Wgu allele

Expression

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Huwe1 Mutation: 63 strains or lines available

References

• Original: J:182446 Kon N, et al., Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice. J Biol Chem. 2012 Feb 10;287(7):5102-11
• All: 5 reference(s)