Oit3^tm1Zgh
Targeted Allele Detail

Summary

• Symbol: Oit3^tm1Zgh
• Name: oncoprotein induced transcript 3; targeted mutation 1, Ze-Guang Han
• MGI ID: MGI:5315854
• Gene: Oit3 Location: Chr10:59258782-59277601 bp, - strand Genetic Position: Chr10, 29.54 cM, cytoband B3
• Alliance: Oit3^tm1Zgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181913
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 1 and 2. Western blot analysis confirmed the absence of protein expression in the liver and kidney, (J:181913)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oit3 Mutation: 45 strains or lines available

References

• Original: J:181913 Yan B, et al., OIT3 deficiency impairs uric acid reabsorption in renal tubule. FEBS Lett. 2012 Mar 23;586(6):760-5
• All: 2 reference(s)