Abcb8^tm1Hard
Targeted Allele Detail

Summary

• Symbol: Abcb8^tm1Hard
• Name: ATP-binding cassette, sub-family B member 8; targeted mutation 1, Hossein Ardehali
• MGI ID: MGI:5315860
• Synonyms: ABCB8^f
• Gene: Abcb8 Location: Chr5:24598661-24615052 bp, + strand Genetic Position: Chr5, 11.57 cM
• Alliance: Abcb8^tm1Hard page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182234
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 1 via homologous recombination. (J:182234)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcb8 Mutation: 35 strains or lines available

References

• Original: J:182234 Ichikawa Y, et al., Disruption of ATP-binding cassette B8 in mice leads to cardiomyopathy through a decrease in mitochondrial iron export. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4152-7
• All: 3 reference(s)