Tesc^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Tesc^tm1Itl
• Name: tescalcin; targeted mutation 1, inGenious Targeting Laboratory
• MGI ID: MGI:5316034
• Gene: Tesc Location: Chr5:118165808-118199943 bp, + strand Genetic Position: Chr5, 57.84 cM, cytoband F
• Alliance: Tesc^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182299
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4, 5, and 6 were replaced by a neomycin resistance gene in reverse orientation. RT-PCR confirmed the absence of normal transcript. A low level of truncsted transcript lacking exon 3 in addition to exons 4, 5, and 6 was detected. Western blot analysis confirmed the absence of protein in brain, heart, and platelets. (J:182299)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tesc Mutation: 35 strains or lines available

References

• Original: J:182299 Ukarapong S, et al., Megakaryocyte development is normal in mice with targeted disruption of Tescalcin. Exp Cell Res. 2012 Mar 10;318(5):662-9
• All: 1 reference(s)