Cfl2^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Cfl2^tm1.1Itl
• Name: cofilin 2, muscle; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:5316057
• Gene: Cfl2 Location: Chr12:54905594-54909662 bp, - strand Genetic Position: Chr12, 23.75 cM, cytoband C1
• Alliance: Cfl2^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182571
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 2 through 4 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the quadriceps, triceps, gastrocnemius, diaphragm, brain, kidney and lung. (J:182571)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfl2 Mutation: 19 strains or lines available

References

• Original: J:182571 Agrawal PB, et al., Normal myofibrillar development followed by progressive sarcomeric disruption with actin accumulations in a mouse Cfl2 knockout demonstrates requirement of cofilin-2 for muscle maintenance. Hum Mol Genet. 2012 May 15;21(10):2341-56
• All: 2 reference(s)