Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Farhad R Danesh |
MGI ID: |
MGI:5316078 |
Synonyms: |
TgcA-ROCK1flox |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:182287
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1.1(Ubc-ROCK1*)Dnsh expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
ROCK1 (6093) |
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Mutation details: A targeting vector containing a ubiquitin C promoter, floxed stop cassette, human cDNA encoding a constituitively active form, and a floxed neo cassette was inserted into the locus. Cre-mediated recombination removed the neo cassette.
(J:182287)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
993 strains or lines available
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Original: |
J:182287 Wang W, et al., Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab. 2012 Feb 8;15(2):186-200 |
All: |
2 reference(s) |
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