Gt(ROSA)26Sor^{tm1.1(Ubc-ROCK1*)Dnsh}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(Ubc-ROCK1*)Dnsh}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Farhad R Danesh
• MGI ID: MGI:5316078
• Synonyms: Tg^cA-ROCK1flox
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(Ubc-ROCK1*)Dnsh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182287
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(Ubc-ROCK1*)Dnsh} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ROCK1 (6093)

  Rock1

  (MGI:107927)

• Mutation details: A targeting vector containing a ubiquitin C promoter, floxed stop cassette, human cDNA encoding a constituitively active form, and a floxed neo cassette was inserted into the locus. Cre-mediated recombination removed the neo cassette. (J:182287)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:182287 Wang W, et al., Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab. 2012 Feb 8;15(2):186-200
• All: 2 reference(s)