Elavl1^tm1.1Bndr
Targeted Allele Detail

Summary

• Symbol: Elavl1^tm1.1Bndr
• Name: ELAV like RNA binding protein 1; targeted mutation 1.1, Jeffrey R Bender
• MGI ID: MGI:5316082
• Synonyms: HuR^fl
• Gene: Elavl1 Location: Chr8:4335382-4375413 bp, - strand Genetic Position: Chr8, 2.0 cM
• Alliance: Elavl1^tm1.1Bndr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182000
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin selection cassette was inserted in intron 2 and a third loxP site was place upstream of exon 2 in intron 1. The selection cassette was subsequently removed as a result of cre expression leaving exon 2 flanked by loxP sites. (J:182000)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elavl1 Mutation: 43 strains or lines available

References

• Original: J:182000 Zhang J, et al., Macrophage beta(2) Integrin-Mediated, HuR-Dependent Stabilization of Angiogenic Factor-Encoding mRNAs in Inflammatory Angiogenesis. Am J Pathol. 2012 Apr;180(4):1751-60
• All: 1 reference(s)