Topbp1^tm1Pmc
Targeted Allele Detail

Summary

• Symbol: Topbp1^tm1Pmc
• Name: topoisomerase (DNA) II binding protein 1; targeted mutation 1, Peter J McKinnon
• MGI ID: MGI:5316209
• Gene: Topbp1 Location: Chr9:103182414-103227627 bp, + strand Genetic Position: Chr9, 55.19 cM
• Alliance: Topbp1^tm1Pmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181920
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 3 - 6 were flanked with loxP sites via homologous recombination. (J:181920)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Topbp1 Mutation: 76 strains or lines available

References

• Original: J:181920 Lee Y, et al., ATR maintains select progenitors during nervous system development. EMBO J. 2012 Mar 7;31(5):1177-89
• All: 3 reference(s)