Pdilt^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Pdilt^tm1Osb
• Name: protein disulfide isomerase-like, testis expressed; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:5316367
• Gene: Pdilt Location: Chr7:119085810-119122712 bp, - strand Genetic Position: Chr7, 63.9 cM, cytoband F3
• Alliance: Pdilt^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182133
• Parent Cell Line: EGR-05 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a neomycin resistance cassette in reverse orientation. Absence of mRNA in testes was confirmed by RT-PCR an absence of protein was established by immunoblot analysis. (J:182133)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pdilt Mutation: 26 strains or lines available

References

• Original: J:182133 Tokuhiro K, et al., Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3850-5
• All: 2 reference(s)