Pum1^tm1.2Hfl
Targeted Allele Detail

Summary

• Symbol: Pum1^tm1.2Hfl
• Name: pumilio RNA-binding family member 1; targeted mutation 1.1, Haifan Lin
• MGI ID: MGI:5316377
• Gene: Pum1 Location: Chr4:130390632-130508875 bp, + strand Genetic Position: Chr4, 63.43 cM
• Alliance: Pum1^tm1.2Hfl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182280
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 8 and 9 along with the neo cassette. Western blot analysis confirmed the absence of protein expression in the testes. (J:182280)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pum1 Mutation: 169 strains or lines available

References

• Original: J:182280 Chen D, et al., Pumilio 1 suppresses multiple activators of p53 to safeguard spermatogenesis. Curr Biol. 2012 Mar 6;22(5):420-5
• All: 6 reference(s)