Hoxa13^{tm1.1(cre)Makm}
Targeted Allele Detail

Summary

• Symbol: Hoxa13^{tm1.1(cre)Makm}
• Name: homeobox A13; targeted mutation 1.1, Marie Kmita
• MGI ID: MGI:5316384
• Synonyms: Hoxa13:Cre, Hoxa13Cre
• Gene: Hoxa13 Location: Chr6:52235833-52237865 bp, - strand Genetic Position: Chr6, 25.41 cM
• Alliance: Hoxa13^{tm1.1(cre)Makm} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181230
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase, Reporter)
• Mutations: Insertion, Intragenic deletion
• Hoxa13^{tm1.1(cre)Makm} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hoxa13 (MGI:96173)

• Mutation details: A cre-IRES-VenusGFP cassette followed by SV40 666bp sequence and neomycin cassette flanked by two Frt sites and a loxP site was inserted at ATG of Hoxa13 gene and entire first exon was replaced.F1 offspring were intercrossed with homozygous FLPeR mice to delete the neomycin cassette. (J:181230, J:224090)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hoxa13 (mouse) Summary of all recombinase alleles driven by Hoxa13. Alliance mouse Hoxa13 gene page

Expression

In Mice Carrying this Mutation:

2 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa13 Mutation: 29 strains or lines available

References

• Original: J:181230 Scotti M, et al., Recruitment of 5' Hoxa genes in the allantois is essential for proper extra-embryonic function in placental mammals. Development. 2012 Feb;139(4):731-9
• All: 10 reference(s)