Kiss1r^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Kiss1r^tm1.1Lex
• Name: KISS1 receptor; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:5316416
• Synonyms: Gpr54^-
• Gene: Kiss1r Location: Chr10:79752805-79758107 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Kiss1r^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181650
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into exon 1. An additional loxP site and a lacZ with a nuclear localization sequence was inserted downstream of exon 5. Cre-mediated recombination removed the coding sequence. RT-PCR confirmed the absence of transcript expression in the hypothalamus. (J:181650)

Disease models

Expression

In Structures Affected by this Mutation:

22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kiss1r Mutation: 21 strains or lines available

References

• Original: J:181650 Garcia-Galiano D, et al., Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology. 2012 Jan;153(1):316-28
• All: 7 reference(s)