Tg(Cebpb-tTA)#Bjd
Transgene Detail

Summary

• Symbol: Tg(Cebpb-tTA)#Bjd
• Name: transgene insertion, Hermann Bujard
• MGI ID: MGI:5316471
• Transgene: Tg(Cebpb-tTA)#Bjd Location: unknown
• Alliance: Tg(Cebpb-tTA)#Bjd page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The tetracycline regulated transactivator protein (tTA) driven by the Cebpb promoter (previously called liver-enriched activator protein or LAP). The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:93000)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1  Disease Model	Col1a1^tm1(tetO-URI1)Ndj/Col1a1^+ Tg(Cebpb-tTA)#Bjd/0	B6.Cg-Col1a1^tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd
cx2  Disease Model	Col1a1^tm1(tetO-URI1)Ndj/Col1a1^tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd/0	B6.Cg-Col1a1^tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd
cx3	Col1a1^tm1(tetO-URI1)Ndj/Col1a1^+ Tg(Cebpb-tTA)#Bjd/0 Trp53^tm1Gev/Trp53^+	B6.Cg-Trp53^tm1Gev Col1a1^tm1(tetO-URI1)Ndj Tg(Cebpb-tTA)#Bjd
cx4	Col1a1^tm1(tetO-YAP1*)Fcam/Col1a1^+ Tg(Cebpb-tTA)#Bjd/0	involves: 129S4/SvJae * C57BL/6

Phenotypes:

Affected Systems	cx1	cx2	cx3	cx4
show or hide all annotated terms
cellular			√	√
decreased hepatocyte apoptosis			√	√
increased hepatocyte proliferation				√
growth/size/body				√
enlarged liver				√
increased liver weight				√
liver hyperplasia				√
homeostasis/metabolism	√
decreased circulating glucose level	√
increased circulating serum albumin level	√
abnormal enzyme/coenzyme level	√
increased circulating alanine transaminase level	√
increased bile salt level	√
increased incidence of tumors by chemical induction	√
liver/biliary system	√	√	√	√
decreased hepatocyte apoptosis			√	√
increased hepatocyte proliferation				√
abnormal liver morphology	√
enlarged liver				√
increased liver weight				√
liver hyperplasia				√
abnormal hepatocyte morphology				√
increased hepatocellular carcinoma incidence	√	√	√
increased liver adenoma incidence	√
liver fibrosis	√
liver failure	√
mortality/aging	√		√
premature death	√		√
neoplasm	√	√	√
increased incidence of tumors by chemical induction	√
increased hepatocellular carcinoma incidence	√	√	√
increased liver adenoma incidence	√
increased metastatic potential	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cx1	cx2
hepatocellular carcinoma IDs hepatocellular carcinoma       DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176 Close	√	√

Tumor Data

List all tumor models in MMHCdb carrying Tg(Cebpb-tTA)#Bjd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:141457 Camargo FD, et al., YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol. 2007 Dec 4;17(23):2054-60
• All: 12 reference(s)