Tg(Slc17a8-icre)1Edw
Transgene Detail

Summary

• Symbol: Tg(Slc17a8-icre)1Edw
• Name: transgene insertion 1, Robert H Edwards
• MGI ID: MGI:5316477
• Synonyms: VG3-Cre, VGLUT3 Cre BAC
• Transgene: Tg(Slc17a8-icre)1Edw Location: unknown
• Alliance: Tg(Slc17a8-icre)1Edw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Slc17a8-icre)1Edw expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc17a8 (MGI:3039629)

• Mutation details: The C57BL/6 mouse bacterial artificial chromosome (BAC) RP24-88H21, containing only the Slc17a8 locus, was modified by targeting a codon optimized cre recombinase (icre), followed by an SV40 polyA signal, into the ATG start site of theSlc17a8 locus. The modified BAC was microinjected into fertilized FVB/N oocytes and transgenic founders were obtained and crossed to mice expressing a cre-dependent reporter. Activity of icre is seen in interneurons in the hippocampus, cortex, striatum, and cerebellum, with some expression seen in amacrine cells of the inner retina. Two of four founder lines expressed cre, and one line was analyzed further. (J:182798)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc17a8 (mouse) Summary of all recombinase alleles driven by Slc17a8. Comparative matrix view of recombinase activities Alliance mouse Slc17a8 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:182798 Grimes WN, et al., Genetic targeting and physiological features of VGLUT3+ amacrine cells. Vis Neurosci. 2011 Sep;28(5):381-92
• All: 37 reference(s)