Astl^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Astl^tm1Lex
• Name: astacin like metalloendopeptidase; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5316737
• Synonyms: Sas1b^-
• Gene: Astl Location: Chr2:127180559-127199571 bp, + strand Genetic Position: Chr2, 61.93 cM, cytoband F
• Alliance: Astl^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:182712
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES, lacZ and neo cassette replaced exons 5 through 7. Immuno-fluorescence localization confirmed the absence of protein expression in the microvillar domain of mature M2 eggs. (J:182712)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Astl Mutation: 23 strains or lines available

References

• Original: J:182712 Sachdev M, et al., Oocyte specific oolemmal SAS1B involved in sperm binding through intra-acrosomal SLLP1 during fertilization. Dev Biol. 2012 Mar 1;363(1):40-51
• All: 1 reference(s)