b2b940Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b940Clo
• Name: Mutant line 940; Bench to Bassinet Program (B2B/CvDC), mutation 940 Cecilia Lo
• MGI ID: MGI:5316783
• Gene: b2b940Clo Location: unknown
• Alliance: b2b940Clo page

2D serial EFIC image stack in the coronal view of mutant 940-006-1 (E16.5) reveals DORV, AVSD (non commited VSD), muscular VSD, and right aortic arch
Click thumbnail to play movie.

Show the 11 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b940Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiovascular defects: Double outlet right ventricle (DORV)/Overriding aorta, atrio-ventricular septal defect (AVSD), ventricular septal defect (VSD), and right aortic arch (RAA)
Noncardiovascular defects: Anopthalmia

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
0606	DORV + AVSD (AV canal)
1300	Ventricular septal defect
1432	Overriding aortic valve
2720	Right aortic arch
4864	Anophthalmia

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)