b2b1060Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b1060Clo
• Name: Mutant line 1060; Bench to Bassinet Program (B2B/CvDC), mutation 1060 Cecilia Lo
• MGI ID: MGI:5316785
• Synonyms: Big Bird
• Gene: b2b1060Clo Location: unknown
• Alliance: b2b1060Clo page

Persistent truncus arteriosus (PTA) and hypoplastic lungs found in mutant 1060-004-1 (E15.5)

Show the 8 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b1060Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis:
Cardiovascular defects: Persistent truncus arteriosus (PTA)
Non-cardiovascular defects: Oligodactyly, craniofacial anomalies, intrauterine growth restriction, hypoplastic lungs, and ectopia cordis.

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0170	Ectopia cordis
0500	Truncus arteriosus
4134	Skull anomaly, congenital

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)