Tg(PAX6)77Ndha
Transgene Detail

Summary

• Symbol: Tg(PAX6)77Ndha
• Name: transgene insertion 77, Nicholas Hastie
• MGI ID: MGI:5316840
• Synonyms: PAX6^YAC, PAX77
• Transgene: Tg(PAX6)77Ndha Location: unknown
• Alliance: Tg(PAX6)77Ndha page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PAX6)77Ndha expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PAX6 (5080)

  Pax6	(MGI:97490)

• Mutation details: The centromeric arm of YAC Y593 (human ICI library) was replaced with an amplifiable vector by homologous recombination in yeast before injection into fertilized mouse oocytes. Five to seven copies were inserted in this line. Additional lines produced include PAX88 and PAX130 (both with two copies) and PAX138 (with 10 copies). The 420 kb YAC contains the entire paired box 6 gene (including 160 kb upstream of promoter P1) and the elongator acetyltransferase complex subunit 4 (ELP4) gene (including familial aniridia breakpoints SGL and SIMO in the last intron) minus its first three exons. (J:34194)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:34194 Schedl A, et al., Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities. Cell. 1996 Jul 12;86(1):71-82
• All: 7 reference(s)